SOX2 and BCL-2 Expressions in Odontogenic Keratocyst and Ameloblastoma
Med. oral patol. oral cir. bucal (Internet)
; 25(2): e283-e290, mar. 2020. tab, ilus
Article
in En
| IBECS
| ID: ibc-196259
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
BACKGROUND:
The purpose of this experimental study was to compare the immunohistochemical expression of SOX2 and BCL-2 in Odontogenic Keratocyst (OKC) and Ameloblastoma (AB) specimens, and to identify a possible correlation in their expression.MATERIAL ANDMETHODS:
Immunohistochemical analysis was performed to evaluate SOX2 and BCL-2 expression in OKC (n = 20) and AB (n = 20). The immunoexpression was analyzed by a quantitative and qualitative scoring system. The comparison between the immunoexpression of SOX 2 and BCL-2 was assessed by the Mann-Whitney U-test. Spearman's correlation coefficient evaluated the correlation between SOX2 and BCL-2 expressions.RESULTS:
SOX2 and BCL-2 expression was observed in all specimens of OKC in the full thickness of the epithelium lining. SOX2 immunostaining was higher in OKC, in comparison with AB samples (P<0.05). BCL-2 immunostaining between OKC and AB was not statistically significant. There was no significant correlation between SOX2 and BCL-2 in OKC and AB specimens.CONCLUSIONS:
SOX2 and BCL-2 expressions in OKC may suggest their relationship with the biological behavior of this lesion, and the higher expression of SOX2 might be an upstream influence on the Hh signaling pathwayRESUMEN
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Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Ameloblastoma
/
Jaw Neoplasms
/
Odontogenic Cysts
/
Proto-Oncogene Proteins c-bcl-2
/
SOXB1 Transcription Factors
Limits:
Adolescent
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Adult
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Aged
/
Child
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Female
/
Humans
/
Male
Language:
En
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2020
Document type:
Article